Sacred Chocolate: Raw, Stone-Ground, Organic & Vegan > Sacred Chocolate Blog > General > Eating Your Way to Happiness: Chocolate, Brain Metabolism, and Mood
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Kristen Morris, San Diego, Calif. Douglas Taren University of Arizona, Tucson, Ariz.
Chocolate has always been considered unique among foods. From its historical use as a sacred substance up to its prominence today as the food of romance, celebration, and indulgence, it has always held a special place in society. We do not classify chocolate as part of any of the four basic plant groups of food (whole grains, vegetables, fruit, and legumes). Nor do we call it a drug. But curiously, chocolate has properties of both. A food is defined as “any substance taken into and assimilated by a plant or animal to keep it alive and enable it to grow and repair tissue; nourishment; nutriment,” while a drug is “a substance used as a medicine or as a narcotic,” or “a chemical substance, such as a narcotic or hallucinogen, that affects the central nervous system, causing changes in behavior and often addiction.” Chocolate is defined as “a paste, powder, syrup, or bar made from cacao seeds that have been roasted and ground.” It contains nutrients, provides nourishment, and fits the definition of a food. Ask chocolate lovers to define chocolate, however, and they will describe it as “the love drug,” “the eighth wonder,” “the food of the gods,” “a wicked pleasure,” “better than sex,” and “the secret drug of happiness.”
It is becoming increasingly clear that chocolate contains several biologically active compounds, some of which have potential mind-altering properties that may explain the feelings that people have toward chocolate . These compounds include: cannabinoid-like fatty acids that are structurally similar to the active molecule in marijuana (tetrahydrocannabinol); methylxanthines, including one of the most widely consumed drugs with documented addictive properties (caffeine); alkaloids including the same compounds that are found in alcohol and that are thought to be partially responsible for alcoholism (tetrahydro-beta-carbolines); and biogenic amines, including phenylethylamine, otherwise known as the “love drug” because it induces physiological and psychological effects similar to those caused by being in love. While each of these pharmacological agents is present only in small amounts, the combined effects of these compounds, together with the unique sensory properties of chocolate, might be sufficient to induce a chocolate high that triggers and reinforces chocolate cravings.
The combined psychological and pharmacological effects of chocolate have been a topic of increasing interest among nutritional scientists who are now localizing in the body and brain the sites where chocolate acts, and identifying the precise compounds involved.
The endorphin effect: the sensory properties of chocolate
Chocolate contains approximately 50% fat and close to 50% carbohydrate; this combination of nutrients results in a powerful effect whereby all brain chemicals (specifically serotonin, dopamine, and opiate peptides) are positioned at optimal levels for positive mood and euphoric feelings. Palatable foods such as chocolate, cakes, and ice cream stimulate the release of brain opiates known as endorphins, which make you feel good and may even increase appetite. As endorphins are chemically similar to morphine, the brain responds to them in the same way as it responds to morphine. These brain opiates are largely responsible for the body’s response to pleasure, stress, and pain, and are known to be involved in drug addictions. It is now believed that cravings for sweet and high-fat foods such as chocolate may be partly mediated by these brain opiates.
If sensory experience, mediated by opiates, rather than chocolate’s drug-like constituents, is the ultimate object of chocolate craving, then only chocolate should satisfy the craving. Investigations involving “white chocolate” have been useful in delineating the extent to which the sensory qualities of chocolate contribute to cravings. “White chocolate” has the texture and sweetness of chocolate as it also contains cocoa butter and sugar. However, because it contains no chocolate liquor, “white chocolate” does not emit chocolate’s distinctive aroma, nor does it contain chocolate’s many pharmacological constituents. In an experiment whose aim was to isolate the sensory effects of chocolate from the potential pharmacological effects, the researchers found that “white chocolate” produced only an intermediate effect in reducing craving, significantly less than milk chocolate, which largely alleviated craving . These findings lend credence to either a notable sensory effect of chocolate’s aroma and/or a pharmacological effect of its biologically active compounds.
Drug-like chemicals in chocolate
Evidence is accumulating to suggest that chocolate contains several pharmacologically active compounds that may have drug-like effects on the body and mind.
Anandamides (cannabinoid-like fatty acids)
One of the most interesting new findings on chocolate’s pharmacological properties is that it may contain a molecule that mimics the actions of cannabinoids. Cannabinoids, including marijuana, have been used medicinally for over 4000 years to treat migraine, muscle spasms, seizures, glaucoma, pain, and nausea. They have also been used recreationally for their mind-altering, relaxing, and mood-elevating effects.
In addition to anandamide itself, chocolate and cocoa both appear to contain two other unsaturated fatty acids, which are chemically and pharmacologically related to anandamide. These fatty acids are known as N-acyl-ethanolamines (NAEs; N-oleoylethanolamine, N-linoleoylethanolamine) and could mimic endocannabinoid ligands such as anandamide either directly (by activating cannabinoid receptors) or indirectly (by slowing the breakdown of anandamide, thereby increasing anandamide levels and prolonging the action in the brain). Elevated brain anandamide levels have been suggested to magnify the sensory properties of chocolate, which are fundamental to craving, and could also interact with other biologically active constituents of chocolate (i.e., caffeine, theobromine) to induce a noticeable sense of well-being. No unsaturated NAEs have been detected in “white chocolate” or in brewed espresso coffee. The two chocolate NAEs also appear to interfere with the ability of the brain to break anandamide down and remove it from the brain and hence may extend the consequent sense of well-being following chocolate consumption.
Critics contend, however, that you would need to eat an enormous amount of chocolate to experience the characteristic high induced by cannabinoids such as marijuana. Some have estimated that it would take around 11 kg of chocolate eaten in one sitting to produce a response similar to that experienced following marijuana use.
Chocolate also contains significant amounts of methylxanthines, most notably caffeine and theobromine (a caffeine-like substance found almost exclusively in chocolate). Both are stimulants, and caffeine can cause noticeable behavioral effects. Although the methylxanthines are bases, they have a very low pKa (0.5) and, hence, are highly fat soluble and are absorbed from the stomach and through the walls of the intestines, easily crossing both the blood-brain and placental barriers. In animals, theobromine appears to have effects congruent to those of caffeine, although theobromine causes less stimulation and takes longer to induce a peak pharmacological effect. Moreover, recent clinical studies have suggested that theobromine suppresses vagus nerve activity, which is responsible for coughing. In fact, theobromine has been shown to be nearly 30% more effective in stopping persistent coughs than the leading medicine codeine. Consequently, chocolate is now being marketed as the new, effective cough suppressant.
While the quantities of methylxanthines in chocolate are variable even within a brand, a typical 1.65-oz Hershey milk chocolate bar contains only 10 mg of caffeine (22 mg/200 g) and 92 mg of theobromine (197 mg/100 g). For comparison, a cup of coffee usually contains 80–100 mg caffeine, and no theobromine. While the relative concentrations of methylxanthines in chocolate are low, the caffeine and theobromine are nevertheless likely to play a large role in the pharmacological effects of chocolate. Although the dosage typically found in chocolate appears to exert only modest, caffeine-like symptoms, the combined effects of theobromine and caffeine in cocoa products may differ from those of either compound alone. Moreover, a recent study demonstrated that when comparing cocoa powder with just the isolated methylxanthines, the two groups exhibited similar pharmacological effects. The researchers concluded that since the cocoa powder (which contains all of the active compounds in chocolate) had similar activity to the isolated methylxanthines, the pharmacological effects of chocolate are most likely largely due to the methylxanthines.
Another group of compounds found in chocolate are the biogenic amines, most notably tyramine and phenyl-ethylamine (PEA). Biogenic amines are naturally occurring, biologically active compounds that act primarily as neurotransmitters and are capable of affecting mental functioning and regulating several bodily processes such as blood pressure and body temperature. Tyramine is an amino acid that acts to contract blood vessels and is often implicated as a major contributor to migraine headaches in susceptible individuals. PEA occurs naturally as a neurotransmitter in the brain and is thought to stimulate the nervous system and produce feelings such as those experienced when a person is “in love.” For that reason, PEA has been touted as the “love drug” and has been credited for chocolate’s aphrodisiac properties.
While PEA is produced naturally by brain tissue, studies have also demonstrated that it is pharmacologically active and stimulatory when administered. PEA initiates the activity of dopamine production and transmission in the brain, thereby stimulating the brain’s pleasure centers.
A recent study conducted in Spain found that the same alkaloid compounds found in alcohol are also present in chocolate (the darker the chocolate, the more alkaloids). Specifically, the researchers demonstrated that ordinary cocoa and chocolate bars contain two groups of alkaloids known as tetrahydro-beta-carbolines (THBCs) and tetrahydroisoquinolines (TIQs) . The concentration of two THBCs in chocolate and cocoa has been found to be comparable to that of alcoholic beverages such as wine, beer, and liquor, which contain a relatively high amount of those compounds.
These same chemicals in alcohol have been found to exhibit neuroactive properties and have been linked to alcoholism. Many recovering alcoholics use chocolate to curb their craving for alcohol, especially early in sobriety. In fact, the book Alcoholics Anonymous actually recommends using chocolate to satisfy alcohol cravings . Interestingly, no connection between compulsive drinking and chocolate craving has been established.
These neuroactive alkaloids in chocolate are currently being investigated for possible influences on mood and behavior. Preliminary evidence suggests that they may influence the production of endogenous opioids (endorphins), the feel-good chemicals produced by the brain. Other studies suggest that THBCs might play a role as neuromodulators via effects on monoamine oxidase (MAO), the enzyme that is largely involved in the production and breakdown of neurotransmitters (i.e., serotonin and dopamine) that are critical to functions such as appetite, motivation, cravings, mood, and sleep. Specifically, THBCs appear to inhibit MAO, thereby potentiating the effects of biogenic amines in chocolate (i.e., PEA, tryptamine, and others), reducing the breakdown of neurotransmitters and extending their duration of action.
The TIQs found in chocolate include salsolinol (SAL) and salsoline. SAL is a dopaminergic active compound, which binds largely to dopamine receptors. These receptors are specifically responsible for reinforcement and reward, and have been associated with neuropsychiatric disorders such as drug addiction. Preliminary evidence suggests that SAL may influence the production of endogenous opioids (endorphins) and the amount of SAL ingested in 100 g of chocolate is sufficient to interact with the dopamine receptors . Although the concentration of SAL in chocolate products is small, the brain effects may be significant, especially in combination with the other biologically active components of chocolate, and SAL has been deemed one of the main psychoactive compounds present in cocoa and chocolate.
It has been suggested that all drugs of abuse act on the brain’s reward system and cause the brain to interpret drug signals as biologically rewarding or potentially important stimuli comparable to food or sex. This may also be true for chocolate. The mere sight and smell of pleasurable foods can cause brain dopamine levels to rise in brain regions associated with food motivation (such as the dorsal striatum). This means that the dopamine reward system can be triggered by food even when there is no pleasure associated with it. The spike in dopamine observed following exposure to palatable foods, like chocolate, is similar to that seen in drug addicts when they are craving drugs.
So what types of chocolate-related cues or signals might the brain interpret as biologically rewarding or significant? Cues such as images, scents, and emotions associated with chocolate activate similar brain regions and circuitries as those activated following exposure to drug-associated cues. A study involving brain scans of normal, hungry chocolate lovers showed that their brains lit up when they saw and smelled chocolate in the same way that the brain of a cocaine addict responds when the addict thinks about his or her next high. Likewise, in a study designed to investigate why cravings for both drugs and chocolate can be triggered by environmental cues that have come to be associated with the craved substance, the researchers found that exposure to chocolate-associated stimuli induces a pattern of gene expression in the prefrontal cortex that shows many similarities to the pattern elicited by drug cues (the prefrontal cortex is a brain region responsible for several aspects of drug addiction) . The researchers concluded that both chocolate and drugs of abuse induce long-term physiological changes in brain regions that are responsible for certain aspects of addiction. So, the brain areas responsible for drug addiction respond to chocolate-related cues in the same way as they respond to drugs of abuse.
The brain of a“chocoholic” also responds to eating chocolate in the same way the brain of a drug addict responds to appeasing a drug craving. In one study, participants melted chocolate slowly in their mouths while their brain activity was measured as they became satisfied and then beyond, to a point where they ate despite feeling satiated. The researchers found that different brain regions were activated selectively depending on whether the subjects were eating chocolate when they were hungry or whether they were continuing to eat chocolate despite being full . For the hungry “chocoholics,” presentation of chocolate significantly increased the metabolism in regions of the brain that are largely associated with addiction (the superior temporal, anterior insula, and orbitofrontal cortex). In contrast, the pattern of brain activity was different for participants when they were full, and eating chocolate was considered aversive. Interestingly, the brain regions that were activated in the hungry “chocoholics” are the same regions that are activated in cocaine users when they have thoughts about the drug. Together, these findings support the idea that the brain may interpret chocolate as a drug and that the activation of this dopamine reward system likely plays an integral role in the explanation of chocolate’s appeal.
Women’s special relationship with chocolate
Why do more women than men experience chocolate cravings? Why is chocolate often an uncontrollable addiction for women, one that can sabotage a healthy diet, weight control and/or disease prevention?
Many scientists believe that the cycle of fat and sugar cravings in women coincides with reproductive needs. Women consistently report heightened fat and sugar cravings during puberty and following ovulation (premenstrually), which allows for building up energy stores in preparation for pregnancy. Men, on the other hand, report preferences for high-protein foods, consistent with their species-survival need for greater muscle mass.
Other scientists explain gender differences and the cyclic nature of food cravings strictly by differences in hormonal production, as women’s cravings for sweet high-fat foods increase dramatically prior to menstruation. Studies have shown that of the 40% of women who experience regular chocolate cravings, almost half experience heightened chocolate cravings before and during menses.
Finally, some researchers suggest that chocolate cravings in women may also have a cultural explanation. Considering the immense amount of chocolate advertising that targets women, and its association with romance, perhaps it is not surprising that women, more than men, have come to associate chocolate with sex, love, and comfort.
6. Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M: Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain 2001;124:1720–1733.
Kristen Morris (maiden name: Bruinsma) is a nutritional scientist with several years of clinical nutrition research experience. Holding a BA in biology from the University of Virginia, and an MS in nutritional science from the University of Arizona, she has been employed as a medical writer for Healthshop.com, has authored several articles published in scientific journals, and has contributed to the research for other scientific articles. Currently employed at a biopharmaceutical company in San Diego, California, she has been a speaker on behalf of the company at pharmaceutical development investigator conferences in the United States and Europe.
Saturday, February 19, 2011 06:17:26 PM
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